China invention patent of Prof GJ Zhang's team regarding reverse of tamoxifen resistance granted-The Key Laboratory for Endocrine-Related Cancer Precision Medicine of Xiamen

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China invention patent of Prof GJ Zhang's team regarding reverse of tamoxifen resistance granted

Pubdate: 2021/01/26 Hits:

On Jan 13, the State Intellectual Property Office of China granted Xiang’an Hospital of Xiamen University an invention patent "hTERT-miR-221/222 sponge and its application in the reversal of tamoxifen resistance in breast cancer (201910364686.5)" with the inventors GJ Zhang, M Chen, YX Ouyang and J Feng.

Currently, tamoxifen-resistant breast cancer patients have significantly higher recurrence and mortality rates due to limited treatment options. Above invention includes a specific compound targeting breast cancer cell’s miR-221/222 which enhances the tumor specificity and efficacy in gene therapy followed by reverse of tamoxifen resistance and therefore provides a potential availability for clinical application.

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