中文EN
Chinese
Home > About us > News > Content
Prof Guo-Jun Zhang’s team revealed that inhibition of Notch1 reverses EMT and chemoresistance to cisplatin via direct downregulation of MCAM in triple-negative breast cancer cells
Pubdate: 2020/12/13 Hits:

Published in International Journal of Cancer, 2020,147(2): 490-504.

Epithelial-mesenchymal transition (EMT) likely contributes to chemoresistance in triple-negative breast cancers (TNBC), but the underlying mechanisms remain unclear. Here, the expression of Notch1 positively associated with melanoma cell adhesion molecule (MCAM), a unique EMT activator, in TNBC tissue samples. High expression of Notch1 and MCAM predicted poor survival, particularly in patients treated with chemotherapy. Notch1 and MCAM levels were significantly higher in cisplatinresistant than wild-type TNBC cells. The findings suggest that Notch1 regulates MCAM in EMT and contributes to cisplatin resistance in TNBC. Targeting the Notch1/MCAM axis might be a potential avenue to enhance therapeutic efficacy in patients with TNBC.

Contact Us
  • Address: Room 304, Chengwei Building, Xiang'an campus of Xiamen University, Xiang'an District, Xiamen, Fujian Province
  • Tel: +86-592-2889270
  • Email：mchen@xah.xmu.edu.cn
Links

Copyrights © 2020 Fujian Key Laboratory of Precision Diagnosis and Treatment in Breast Cancer / The Key Laboratory for Endocrine-Related Cancer Precision Medicine of Xiamen. All rights reserved. Republication or redistribution of material on this website is prohibited without the prior written consent of Fujian Key Laboratory of Precision Diagnosis and Treatment in Breast Cancer / The Key Laboratory for Endocrine-Related Cancer Precision Medicine of Xiamen.

The information and contents on this website are provided for general information purposes and references only, and on the understanding that no any medical/academic advice or recommendation is being rendered or given. All information and contents are not warranted to be absolutely correct, accurate, complete or up-to-date. All materials and functions are not warranted to be uninterrupted, error-free or virus/harmful element-free. We are entitled to delete, suspend or edit any information (including but not limited to service details and charges), contents and materials and stop any functions from time to time without prior notice or giving any reasons. We accept NO responsibility for any losses, damages or misunderstandings incurred for any causes whatsoever in relation to or as a result of the use of this website.